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Triple reuptake inhibitors and MAOIs

Posted by Tom Twilight on October 20, 2005, at 12:44:59

In reply to Re: Triple reuptake inhibitor trial, posted by med_empowered on October 19, 2005, at 20:40:13

I don't mean to contradict anyone, and I'm just speculating, but I don't think triple re-uptake inhibitors will be the same as MAOIs.

For one thing their mechanism of action is very different, so that probably equalls different results.
Secondly the MAOI drugs we have do not act soley through MAOI inhibition.
Nardil, Parnate and Moclobemide are all MAOIs, but there all totaly different drugs.

Nardil is skewed towards Serotonin and prevents the breakdown of GABA, Parnate is skewed towards Dopamine and enhances dopamine release (I think).

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poster:Tom Twilight thread:568913
URL: http://www.dr-bob.org/babble/20051017/msgs/569301.html