Posted by SLS on October 14, 2005, at 11:05:03
In reply to Need something to hope for., posted by denise1966 on October 14, 2005, at 6:59:55
Hi Denise.
I don't think there is anything radically different that is due to appear this year. The Emsam patch is due to come out next year, I believe. It is a new transdermal delivery system for an old drug, selegiline (deprenyl, Eldepryl). Selegiline is a MAOI that is selective at low dosages for the MAO-B enyzme and used previously for Parkinsons Disease. People who have tried Emsam have said that it works for depression better than the oral preparation. I don't know what dosages are used. Perhaps they are high enough to allow for MAO-A to be inhibited too.
Agomelatine is an interesting drug that should appear in Europe within a year. It is a melatonin receptor agonist and an antagonist at 5-HT2c receptors. This is quite different from anything else being marketed.
Gepirone might yet make it to market as the drug company has submitted new data to the FDA. It is a cousin of Buspar and is said to have antidepressant properties. Like Buspar, it is a 5-HT1a partial agonist.
You can find other submissions at:
http://www.neurotransmitter.net/newdrugs.html
Phase III drugs are considered imminent, but can still take 2 years to come through.
I guess a good question to ask yourself is, which existing drugs are new to you?
Have you tried both Nardil and/or Parnate? Have you combined either drug with another antidepressant like desipramine or Wellbutrin?
Have you tried adding lithium or thyroid?
Have you tried adding an anticonvulsant mood stabilizer? Which ones?
- Scott
poster:SLS
thread:566744
URL: http://www.dr-bob.org/babble/20051010/msgs/566805.html