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Re: Woo hoo!! I've got the wellbutrin! cockeyed

Posted by Jedi on September 14, 2005, at 1:25:38

In reply to Re: Woo hoo!! I've got the wellbutrin! Sebastian, posted by cockeyed on September 13, 2005, at 19:22:05

> Hi, My wife told me that a number of people on her overstressed staff were taking wellbutrin. My Pdoc gave me samples of 300mg XR. Okay, i seem to be feeling a bit better, also taking 40 mgs. of prozac. But I'm a large person, 290, 6'2
> and I wonder about this "Well, let's start at the low dosage." bit.

Hey Cockeyed,
The dosage prescribed might not be as low as you think. Fluoxetine and bupropion are metabolized by the same enzyme P450-CYP2D6. This can lead to higher blood levels of either compound. By starting at lower levels, the potential chance of a drug interaction can be minimized.
Take care,
Jedi

Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15692832&query_hl=3
Eur J Clin Pharmacol. 2005 Apr;61(2):119-25. Epub 2005 Feb 4.
Co-prescription of cytochrome P450 2D6/3A4 inhibitor-substrate pairs in clinical practice. A retrospective analysis of data from Norwegian primary pharmacies.


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