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Re: Neurogenesis

Posted by SLS on September 13, 2005, at 0:10:49

In reply to Neurogenesis, posted by Pfinstegg on September 12, 2005, at 23:22:09

Hi Pfinstegg.

> I recently noticed an article which said that TMS, at regular intervals. plus the right AD is producing about a 70% remission rate. That's what has worked for me, so I have a bias in favor of it;

What was the suggested interval between TMS treatments?

Thanks.

I am not so convinced that neurogenesis is the cause of improvement as it is the result. Not yet, anyway.

I would sure like them to study more closely medication "poop-out" or tachyphylaxis. My responses to antidepressants and mood-stabilizers persist for only three days, usually occurring between 7 and 14 days after initiating treatment. The consistency of this pattern is remarkable. For the moment, I am somewhat focused on presynaptic events to account for this pattern. For those people whose improvement lasts for months or years before relapse occurs, it may be that whole brain circuit systems must be considered, as you described. I would be inclined to look at changes in postsynaptic receptor sensitivities or second messenger / gene transcription systems as the facilitators of these contratherapeutic events.


- Scott

 

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