Posted by Jedi on September 4, 2005, at 4:03:21
In reply to Serotonin Syndrome, posted by tygereyes on September 3, 2005, at 11:55:12
> Does 100 mg of Desipramine and 100 mg of Zoloft put me at risk for serotonin syndrome?
>
> Or is this restlessness and excitability because I (theoretically) have Bipolar II Disorder?
Hey Tygereyes,
Sertraline can affect the level of desipramine in the blood. The half-life of desipramine is affected by sertraline inhibiting the enzyme CYP2D6 from metabolizing desipramine. TCAs can be fatal in overdose, so be careful with this combination. I would suggest getting a desipramine blood level to be sure. A higher than expected level of desipramine in the blood would explain your symptoms.
Good Luck,
JediThe effect of sertraline on the pharmacokinetics of desipramine and imipramine.
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9284850&query_hl=1
Kurtz DL, Bergstrom RF, Goldberg MJ, Cerimele BJ.“OBJECTIVE: To examine the pharmacokinetic interaction between the selective serotonin reuptake inhibitor sertraline and the tricyclic antidepressants desipramine or imipramine in 12 healthy male subjects. … CONCLUSIONS: This pharmacokinetic interaction is likely the result of an inhibition of CYP2D6 tricyclic metabolism by sertraline. When a tricyclic antidepressant, such as desipramine or imipramine, is coadministered with sertraline, lower dosages of the tricyclic agents may be necessary to prevent elevated tricyclic levels.”
poster:Jedi
thread:550345
URL: http://www.dr-bob.org/babble/20050901/msgs/550536.html