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Re: I Having Sexual Side Effects on Wellbutrin XL! » theo

Posted by Chairman_MAO on August 30, 2005, at 13:57:51

In reply to I Having Sexual Side Effects on Wellbutrin XL!!!!!, posted by theo on August 27, 2005, at 11:19:17

I have this problem on any adrenergic drug. I feel that it is under-reported in the literature, given that NE uptake inhibition--which bupropion and/or one of its metabolites does--stimulates alpha-adrenoreceptors in the male genitalia causing the shrinkage. To rememdy this you need a PDE5 inhibitor (I recommend tadalafil) or a drug which antagonizes the alpha-adrenoreceptors. You can try yohimbine, but that is probably too stimulating for someone already on Wellbutrin. A great drug to try is tamsulosin (Flomax), which is selective for the receptors in the genitals.

You could also add trazodone or nefazodone, both of which have an alpha-1 blocking effect and get a better AD response at the same time.

Best of luck! Any questions, babblemail me, as I have done extensive research in this area because it affected me.


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