Posted by Dave001 on August 29, 2005, at 4:05:36
In reply to Re: Neurotoxicity is a pretty sketchy term, posted by Dave001 on August 29, 2005, at 2:30:32
<snip>> There are obvious difficulties with conducting studies of neurotoxicity
> in humans, but at least non-human primates make it much easier to
> extrapolate doses. It's plausible that say, 10 mg/[*kg*/]day in rats is
> comparable with doses used in humans in clinical practice. Adjusting for
> body surface area alone would account for much of the difference, and
> then one must consider the much faster rate at which amphetamines are
> metabolized in rats (independent from body mass/surface area variables).Oops. I had _meant_ to say 10 mg/kg/day. I couldn't go back to edit my
post, so please make note of the correction.
poster:Dave001
thread:547372
URL: http://www.dr-bob.org/babble/20050827/msgs/547995.html