Posted by SLS on August 27, 2005, at 9:36:39
In reply to Re: RU486 OTC?, posted by Ocracoker16 on August 26, 2005, at 22:44:31
> No, mifepristone is not the morning after pill. Mifepristone is a pill which induces abortion by blocking action of progesterone.
Mifepristone (RU-486) is also a potent blocker of cortisol receptors. It is currently being studied to treat bipolar depression. It seems to have provided evidence of being efficacious for psychotic depression. Both of these disorders are characterized by over active HPA function and increased levels of cortisol. I believe this is also true of melancholic (typical/endogenous) unipolar depression as well.
We will have to see whether or not mifepristone would be of use in treating atypical unipolar depression for which cortisol levels are often decreased.