Posted by Shawn. T. on August 22, 2005, at 15:47:47
In reply to Why do SRI's make my nose stopped up?, posted by 4WD on August 22, 2005, at 12:52:54
My guess is that 5-HT3 receptors are involved. Serotonin- induced nasal secretions are correlated with increases in substance P release (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2444128&dopt=Abstract). 5-HT3 receptor activation has been associated with substance P release, so that's where I'm placing my bet. You could take a 5-HT3 or NK1 receptor antagonist, but you'll probably want to consider OTC decongestants like pseudoephedrine before asking your doctor about the more expensive prescription medications.