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Re: Neurogenerative properties of lithium

Posted by linkadge on August 7, 2005, at 16:58:13

In reply to Neurogenerative properties of lithium, posted by Squiggles on August 7, 2005, at 12:11:59

I would think that the neurorestorative properties of lithium are just some of the properties. It also stabalizes glutamate neurotransmission which is probably neuroprotective.

It is my understanding that the disease causes the atrophy, not the other way around. Meaning that when the drug is stopped, the disease will start again and the atrophy will probably return.
(the disease will start first then probably the atrophy later)

Divalproex has some neuroregenerative properties but not nearly to the same degree as lithium. Carbamazapine has little effect in this regard.

It is funny because most antidepressants show some ability to grow new neurons in the hippocampus. Lithium affects this region, but also affects the frontal cortex (subgenual prefrontal), grey matter etc.


Linkadge



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