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Re: Tamoxifen for the treatment of acute mania

Posted by linkadge on July 22, 2005, at 19:09:22

In reply to Tamoxifen for the treatment of acute mania, posted by ed_uk on July 22, 2005, at 18:11:55

PKC (epsilon) inhibitors may also be usefull in the treatment of anxiety disorders.

There is a link between PKC activation and reduction in the activities of the GABA(a) receptor.

According to the below study, activation of the 5-ht2 system activates PKC and decreases GABA(a) responsivness.

This may be why 5-ht2 blockers have anxiolitic and perhaps antimanic activities. Probably upstream of PKC and GABA(a).

I think PKC inhibitors also increase the responsiveness of the GABA(a) receptor.

http://www.jneurosci.org/cgi/content/short/21/17/6502


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URL: http://www.dr-bob.org/babble/20050718/msgs/531802.html