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Re: The Pain of Treatment Resistant Depression Ron Hill

Posted by Ilene on July 15, 2005, at 15:32:15

In reply to Re: The Pain of Treatment Resistant Depression Ilene, posted by Ron Hill on July 15, 2005, at 14:31:43

> I don't make it over there. I stick to this board and Admin. As an aside, I may have to leave PB soon, but I want to follow up with your first. If I dissappear, feel free to contact me via babblemail.
>

Sorry you might have to leave.


> For me, my atypical depression seems to have dopaminergic roots. I'm six weeks into a trial of very low dosage Selegiline. It's too early in the trial to proclaim victory, but so far, I'm getting good results. It's taken me a while to find the best dosage, but I think I'm onto something. Have you every looked into the dopaminergic tx approach?
>

I'm not sure. I've tried a lot of drugs.

> > > What is your dx?
>
> > Unipolar depression.
>
> No cycling at all, correct? Never any hypomania, right?
>

No cycling/hypomania.


> I wonder if you are experiencing SSRI Induced Apathy. Raising serotonin levels with an SSRI can, in some cases, lower dopamine levels resulting in apathy, low motivation, anergy, anhedonia, etc. Does the Abilify reduce your apathy at all?
>

I actually feel a little better now than before I started the Prozac. Besides, Prozac was one of the only two drugs that ever worked for me. The other was desipramine. The Abilify doesn't do a thing.


> Have you ever tried adding a pstim (e.g.; Adderall XR, Concerta, Provigil, etc) or an MAOI-b like Selegiline? If you've never added a dopaminergic medication to your cocktail, I'd be curious to see what it would do for you.
>

I tried Provigil and one of the amphetamine types; I think it was dexedrine. I used to be on Marplan; I don't know if it's an MAOI-b or not.

I.


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