Posted by linkadge on June 29, 2005, at 19:37:45
In reply to Re: Jay, I think you've tried cyproheptadine too? » ed_uk, posted by jay on June 29, 2005, at 17:48:23
I found that cyproheptadine was good for a few things.
It is a good antianxiety (esp for physical anxiety), that terrable feeling like your brain is attacking your body.
I have found that yes it can induce depression sometimes, but at other times it seems to be a very helpful antidepressant.
I think that SSRI's mainly work via HPA axis stimulation. The reason cypro may lead to depressive relaspe is probably due to its effects on sleep. It improves the quality of sleep, makes you sleep really deep. It enhances melatonin production. When I was on SSRI's, the only times I felt really goood was when they totally disrupted my sleep. No nighmares/thrashing in sleep = no response.
The 5-ht2c antagonism can lead to increased appetite, but also increase dopamine release in the NAA.
I think the immediate drop in cortisol can depress you, but it may act to regulate HPA axis more like TCA's in the long run.
It helped with migrane, and it helped with SSRI induced akathesia/apathy/hyperactivity.
Unfortunately it is too much antihistamine/anticholinrgic compared to antiserotonin, so you do get a lot that you don't want.
I find it usefull, and always keep some with me. I don't use it on a regular basis. It also helps with SSRI anorgazmia, but sometimes the effect is not immediate, and you need to take it for a few days to have returned sex drive.
I also found it does have antipsychotic qualities.
Its not a wonder med, but its good to take it a few times to see what it does for you.
Its funny, if you take it for a long time, and then suddenly discontinue, you almost get an LSD like effect.
I did something really weird. I took it alone for a week, then suddenly stoped it and then took celexa. I must have had a lot of rebound 5-ht2a/c stimulation which produced a lot of funky visual crap. I was scared to approach the railway lights because they looked like evil knights staring into my soul.
I would really like to find a potent/selective 5-ht2a antagonist.
Linkadge
poster:linkadge
thread:521042
URL: http://www.dr-bob.org/babble/20050627/msgs/521237.html