Posted by Jazzed on June 26, 2005, at 11:58:59
In reply to Re: But wait ? How does this make sence?, posted by SLS on June 25, 2005, at 21:30:33
> The dynamics of the system include many feedback loops that help keep it running at a nominal velocity. Perhaps people with the each version of the 5-HT transporter display a different complementary rate of second messenger events and the expression of varying numbers of membrane receptors. For example, there is a *higher* number of 5-HT2a post-synaptic receptors found post-mortem in suicide victims. Yet, 5-HT1a autoreceptors are upregulated as well. It is counterintuitive to think that a reduced rate of reuptake would produce such a state, except that the upregulated autoreceptors work to reduce the rate of synthesis and release of serotonin. This would help to balance a sluggish reuptake system. It seems to me, however, that such a system would not tolerate perturbations very well. There isn't much room left for homeostatic mechanisms to compensate for stress and overactivity. On the other hand, a greater number of transporters allows for greater variation in the sensitivities of receptors to maintain homeostasis during stressful times because they are not upregulated to begin with.
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> - Scott
Scott,What DO you DO for a living? Your posts are always so intelligent. Sometimes they go SO over my head, but I always find them interesting, so I try to hang in there and "get it". I would love to be intelligent. I find others posts to be that way too, like linkadge and larry, and lots of others. I missed the gene pool on this one.
Jazzy
poster:Jazzed
thread:518841
URL: http://www.dr-bob.org/babble/20050622/msgs/519239.html