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Re: best AP for anxiety? chess

Posted by BIGDaddyachmed69 on May 10, 2005, at 10:54:45

In reply to Re: best AP for anxiety? chess, posted by Cairo on May 10, 2005, at 9:05:24

> What are the differences between Risperdal, Seroquel and Zyprexa on hitting receptors? Any good charts/sites that describe this?
>
> Cairo

Now, I got this information from http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html...I'm assuming it's fairly accurate.

Risperdal antagonizes 5-HT(serotonin)2a receptors primarily, and to a lesser extent DA(dopamine)2 and NE(norepinephrine)-alpha receptors. It's also an H(histamine)1 receptor antagonist.

Seroquel is mainly a 5-HT2a and NE-alpha1 receptor antagonist. It targets the DA2 and H1 receptors as well...and according to this website, it's a "sigma antagonist". I don't know what that means.

Zyprexa blocks acetylcholine muscarinic receptors, is an H1 receptor antagonist and again a 5-HT2a antagonist. The blockade of muscarinic receptors is responsible for those notorious anti-cholinergic side-effects caused by certain medications, but I'm pretty sure that in this case they're not all that prevalent. The DA1, 2, 5-HT2c, and NE-alpha1 receptors are antagonized as well to an extent.

It looks like the two other anti-psychotics have unique features...Geodon is mainly a 5-HT2a antagonist, and a DA2 and 3 receptor blocker. But it's also a 5-HT1a agonist apparently, and very mildly inhibits the reuptake of norepinephrine and serotonin. It also antagonizes the 5-HT1d receptor...wonder what that does. Abilify is a DA2 partial agonist, which means it's supposed to sort of normalize dopamine levels. It's also a DA3 antagonist. It antagonizes the 5-HT2a receptor, not as much so, and is also a 5-HT1a agonist.

I read what I had to, summarized it...but I don't get how many of the actions of these drugs ultimately affect us.


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