Posted by cache-monkey on April 30, 2005, at 20:00:24
In reply to sister on Seroquel, posted by mogger on April 30, 2005, at 14:56:52
I'm interested in this combo, since I think it might be my next trial... Out of curiousity what dose of selegiline is she on?
Smaller doses (e.g. 25-100 mg) are what I usually see just for sleep. But at a therapeutic dose (e.g. 300 mg) it can be additionally beneficial for anxiety/depression. I'm actually considering it in that range as a mood stabilizer due to a soft bipolar tendency.
If it's just for sleep, I could see a small dose at night helping. Some people do report sedation carrying into the next day, but from what I've read many (most?) wake up fine, especially after getting used to the drug for a little while. So it might be something try and see how it goes.
Other similar options for sleep could be low-dose trazodone, or benadryl at night. These, as well as Seroquel, work for sleep by targetting the histamine receptor. Other sleep options are available, too, e.g. Ambien, or the new Lunesta, which is supposed to have fewer issues with tolerance. These have a different mechanism of action.
If the goal is augmenting for some therapeutic benefit, I've heard that for many (but not all) sedation at, e.g. 300 mg, is intense for a couple of weeks and then dissapates. To the extent that some lose much of the sleep benefit. Something to do with adaptive down-regulation of the histamine receptors.
Just my sense based on various things I've read...
Hope this helps,
cache-monkey> Hello,
> does anyone know whether 300mg of Seroquel is that high of a dose? I am just worried that she will become dull and sluggish as the Selegiline is working really well for but she is having trouble sleeping. She uses Seroquel just for sleeping. Any thoughts would be great.
poster:cache-monkey
thread:491950
URL: http://www.dr-bob.org/babble/20050428/msgs/492070.html