Posted by SLS on April 28, 2005, at 6:17:11
In reply to Re: Keppra » SLS, posted by theo on April 27, 2005, at 22:42:59
> > Imipramine is the "gold standard" by which other antidepressants have been measured. If you are not afraid of anticholinergic side effects (dry mouth, blurred vision, constipation, difficulty in urination, etc.), you will probably enhance your chances of getting well by trying imipramine instead of desipramine.
> >
> >
> > - Scott
>
> So between nortriptyline, desipramine and imipramine, nortriptyline would have the least side effects and imipramine the most? With TCA's are side effects dose related?The anticholinergic side effects of TCAs are dose related. I'm partial to nortriptyline right now because it is somewhat less selective than desipramine for amine uptake inhibition. I find nortriptyline to be a more pleasant drug to be on.
Years ago, an idea circulated that responses to desipramine and nortriptyline were mutually exclusive. If you responded to one, you would tend not to respond to the other and vice versa. Again, with antidepressants, it is important not to generalize your reaction to one drug to an entire class.
- Scott
poster:SLS
thread:487624
URL: http://www.dr-bob.org/babble/20050428/msgs/490715.html