Posted by Elroy on April 27, 2005, at 20:10:58
In reply to Who prescribes selegeline, posted by linkadge on April 24, 2005, at 12:12:57
If you search The Web, you will find some VG studies involving the use of selegiline for depression (as well as being an excellent life-extension compound). And very safe. Of course, we're talking LOW DOSE (10mg or less, possibly up to 15 mg but not any more) of selegiline.
Here's some general links of selegiline (deprenyl):
http://qualitycounts.com/fpdeprenyl.html
http://www.selegiline.com/refs/
http://www.smart-drugs.com/ias-Info/ias-deprenyl.htm
QUOTE: "L-deprenyl is what good pharmaceuticals are all about. First it is exceptionally safe, second it protects and enhances mental function, mood and even libido, thirdly, it may even extend life. Imagine a safe agent that enhances both the quality and length of life." - Julian Whitaker M.D. - Health and Healing Newsletter, Whitaker Wellness Institute, Newport Beach, California.... Also: Mendlewicz and Youdim reported a marked improvement in 14 patients with unipolar or bipolar depression who received selegiline hydrochloride 5 mg three times daily for 40 days compared with 13 patients given placebo. (1) Similarly, Birkmayer et al. reported benefit in an uncontrolled study in 102 outpatients and 53 inpatients with unipolar depression who received selegiline hydrochloride 5 to 10 mg daily in association with phenylalanine 250 mg daily- about 70% of these patients, in whom conventional antidepressants were not effective, were reported as having complete remission. END QUOTEhttp://smart-drugs.net/ias-deprenylJS.htm
QUOTE: In 1978 Mendelwicz and Youdim treated 14 depressed patients with 5 mg deprenyl plus 300 mg 5-HTP 3 times daily for 32 days. (1) Deprenyl potentiated the antidepressant effect of 5-HTP in 10/14 patients. 5-HTP enhances brain serotonin metabolism, which is frequently a problem in depression (37), while deprenyl enhances dopamine/noradrenalin activity. Under-activity of brain dopamine, noradrenalin and serotonin neural systems are the most frequently cited biochemical causes of depression (18,19,37), so deprenyl plus 5-HTP would seem a natural antidepressant combination. ALSO: In 1991 H. Sabelli reported successful results treating 6 of 10 drug-resistant major depressive disorder patients. (9) Sabelli used 5 mg deprenyl daily, 100 mg vitamin B6 daily, and 1-3 grams phenylalanine twice daily as treatment. 6 of 10 patients viewed their depressive episodes terminated within 2-3 days! Global Assessment Scale scores confirmed the patients’ subjective experiences. Vitamin B6 activates the enzyme that converts phenylalanine to PEA, so the combination of low-dose deprenyl, B6, and phenylalanine is a bio-logical way to enhance both PEA and catecholamine brain function, and thus to diminish depression. END QUOTEhttp://www.selegiline.com/pea.html
http://www.selegiline.com/depplus.html
http://www.restoreunity.org/improving_deprenyl.htm
My personal favorite:
http://www.dr-bob.org/babble/20041211/msgs/430276.htmlSo you might want to consider printing out some of these and having an "informative chat" with your doc and see if you can't tactfully bring him around for a trial venture???
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X> Why are some doctors more familliar with the usage of alternative drug therapies such as selegeline ?
>
> My doctor wondered what on earth I was asking about a parkinson's med for, as I didn't have parkinsons.
>
> Linkadge
poster:Elroy
thread:488726
URL: http://www.dr-bob.org/babble/20050423/msgs/490546.html