Posted by rod on April 3, 2005, at 13:10:06
In reply to Why does nicotine solve all my psychiatric problem, posted by linkadge on April 3, 2005, at 11:01:59
> Nicotine is by far the best antidepressant I have taken. It helps my anxiety and my motivation without causing any side effects. It supposedly is a potent 5-ht1a agonist.
>cool !
> Why cant we just have a really strong 5-ht1a agonist. Why load numerous receptors with serotonin when only one needs it ??
>
>
> LinkadgeHmm correct me if a am wrong, but as far as I know (a doc once told me), the different SSRIs have also different affinities within the 5-ht receptor family. Citalopram for example, has the biggest diffenerce in affinity to the 1A versus the rest (it "prefers" the 1A reuptake pump). Prozac ist the most unselective of the SSRIs.
I have read (but cant find the link) that even Clomipramine "prefers" the 1A receptor more than the other ones like 5-ht5, h-ht7 etc. The "selective" in the term SSRI does not mean its a serotonin only drug but it has selective effect within the 5-ht receptor family.Maybe someone knows something like a chart, with the affinities within the 5-ht family for different drugs are listed?
And correct me if I got fooled by this doc :-)
Roland
poster:rod
thread:479258
URL: http://www.dr-bob.org/babble/20050330/msgs/479302.html