Posted by KaraS on April 2, 2005, at 15:54:49
In reply to Re: Anyone TIRED on Wellbutrin XL? » islandangel, posted by franco neuro on April 2, 2005, at 11:12:05
I just read your post to Ed below in another thread and you are already thinking about the hypersensitive dopamine autoreceptors theory. I just wanted to add that when King Vultan was building up on Parnate, he claimed to feel awful at each dosage increase. Then he would start feeling better after about a week. He thought that might be the downregulation taking place. When I first tried selegiline (5 mgs.) it made me sleepy. After I took it a few times (I always took it in the late morning) one evening about 8-9 hours after I took it, I felt stimulated (like I was expecting to feel from this all along). I think this may have been a result of downregulation. I'm not sure why Dr. Goldstein thinks or thought that only amisulpride/sulpiride could address this problem. As Todd posited (King Vultan) why wouldn't medications like Parnate, selegiline, Ritalin downregulate dopamine autoreceptors in the same way that SSRIs downregulate serotonin autoreceptors? Anyway, he was doing so well on Parnate that he is no longer posting anymore. :-(
Kara
poster:KaraS
thread:473033
URL: http://www.dr-bob.org/babble/20050330/msgs/479011.html