Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Confused Re: Interaction btw. Valium Depakote

Posted by cache-monkey on March 29, 2005, at 13:09:27

Hey all,

I'm going to be adding Depakote to my current low-dose (too low, really) Valium monotherapy.

The PI for Depakote states, regarding the interaction between Depakote and Valium:
"Valproate displaces diazepam from its plasma albumin binding sites and inhibits its metabolism. Co-administration of valproate (1500 mg daily) increased the free fraction of diazepam (10 mg) by 90% in healthy volunteers (n=6). Plasma clearance and volume of distribution for free diazepam were reduced by 25% and 20%, respectively, in the presence of valproate. The elimination half-life of diazepam remained unchanged upon addition of valproate."

I'm not quite sure what this means. If anyone can explain, I would be much obliged.

Best,
cache-monkey

Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in
This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:cache-monkey thread:477227
URL: http://www.dr-bob.org/babble/20050326/msgs/477227.html