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Re: Tegretol, Dilantin..... ed_uk

Posted by Ritch on March 22, 2005, at 10:12:29

In reply to Re: Tegretol, Dilantin..... Ritch, posted by ed_uk on March 22, 2005, at 8:22:20

> Hi Mitch!
>
> >Actually, not *soon*, if at all really. After reading about all the hassles with drug-drug interactions... I'm thinking I'll just stay on the Depakote, by itself.
>
> :-) OK, I suppose it would be a hassle!
>
> >Hey, isn't there a non-linear pharmacokinetic thing with Depakote as well....
>
> I'm not sure- it's easier to titrate than phenytoin though!
>
> Are there any other treatments that you'd like to try?
>
> Best regards,
> Ed.


I was just wondering about the specific "problem" of serum protein binding by medications and how this presents an entirely different "interaction" phenomenon from the kind you typically read about regarding liver enzymes and elimination. From what I remember I think the serum protein binding is what creates a significant interaction between Depakote and Lamictal. I was just curious if there were any other meds (off the top of your head), which could interact in this manner. Actually, I'm a little worn out from "trying" different meds. At this point, I'm more interested in avoiding any unintended interactions with the meds I do take (Depakote and clonazepam). Thanks for your help!


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poster:Ritch thread:471753
URL: http://www.dr-bob.org/babble/20050322/msgs/473962.html