Posted by SLS on February 9, 2005, at 20:19:11
In reply to still going thru stim w/d, posted by zeugma on February 7, 2005, at 18:05:34
> I'm still going thru stim withdrawal, and now that I'm going to be d/c'ing Strattera, I decided to stay at 75 nortrip for the time being because I am so d*mmed anxious about the effect these drugs are having on me that I want to make as few changes as possible in the space of 24 hours. The strattera dysphoria is a peculiar, anhedonic feeling that should dissipate within a day or two independently of any antidepressant effect of other drugs. (I suppose that Ki of 95 nM is low enough in my case...) I wonder why the TCA's are so much more reliable than these new drugs. My own theory is that since we don't have a clue about the brain yet, relatively speaking, it is the serendipitious discoveries that yield better meds, because we literally don't know what we're aiming at and are more likely to produce favorable results by pure chance than by 'designing' a drug 'rationally.'
I wonder what would happen if you were to take an anticholinergic like Akineton...