Posted by Larry Hoover on January 24, 2005, at 5:56:30
In reply to Re: MAYBE WE SHOULD RETHINK THE BENADRYL GUYS!!! » dancingstar, posted by corafree on January 23, 2005, at 13:38:16
> Tks DS...got that...what a giant link!!!
>
> So, seems maybe Allegra preferred over Benadryl in second post.That's not what this article is saying at all.
Some SSRIs inhibit the 3A4 liver enzyme. That can cause an induced (unnatural) toxicity of the listed antihistamines (in the first post on that page).
Diphenydramine (Benadryl), chlorpheniramine (Chlortripilon?) and loratidine (Claritin) do not require the function of 3A4 to be cleared from the system, and are safe to use with antidepressants. Diphenhydramine has anticholinergic activity, which may be why it is especially useful during withdrawals.
Lar
poster:Larry Hoover
thread:13781
URL: http://www.dr-bob.org/babble/20050124/msgs/446641.html