Posted by ace on January 23, 2005, at 20:35:18
In reply to Seroquel for anxiety/ocd?, posted by chess on January 23, 2005, at 9:26:47
> anyone know if Seroquel works for anxiety and/or ocd?
Sure thing buddy! It can and has worked extremely well for both! I am currently changing to 200mg or so Seroquel for my OCD and anxiety...Zyprexa was preety good for OCD, but I was too fat! Check out the below about Seroquel....
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A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors.Denys D, de Geus F, van Megen HJ, Westenberg HG.
Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands. D.A.J.P.denys@azu.nl
BACKGROUND: Although serotonin reuptake inhibitors (SRIs) are the most effective pharmacologic treatment currently available for patients with obsessive-compulsive disorder (OCD), 40% to 60% of patients do not respond to this treatment. This study was conducted to evaluate the efficacy and tolerability of quetiapine in addition to an SRI for treatment-refractory patients with OCD. METHOD: Forty patients (10 men/30 women, mean +/- SD age = 35.2 +/- 12.1 years; range, 18-60 years) with primary OCD according to DSM-IV criteria who were recruited between February 2001 and December 2002 were randomly assigned in an 8-week, double-blind, placebo-controlled trial to receive dosages titrated upward to 300 mg/day of quetiapine (N = 20) or placebo (N = 20) in addition to their SRI treatment. At entry, all patients were unresponsive to courses of treatment with at least 2 different SRIs at a maximum tolerated dose for 8 weeks. During the study, primary efficacy was assessed according to change from baseline on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). A responder was defined as having a final Clinical Global Impressions-Improvement scale rating of "very much improved" or "much improved" and a decrease of > or = 35% in Y-BOCS score. RESULTS: An intent-to-treat, last-observation-carried-forward analysis demonstrated a mean +/- SD decrease in Y-BOCS score of 9.0 +/- 7.0 (31%) in the quetiapine group and 1.8 +/- 3.4 (7%) in the placebo group (F=16.99, df=1,38; p <.001). Eight (40%) of 20 patients in the quetiapine group and 2 (10%) of 20 patients in the placebo group were responders (chi2=4.8, df=1, p=.028). The most common side effects in the quetiapine group were somnolence, dry mouth, weight gain, and dizziness. CONCLUSION: The results of this study show that quetiapine in addition to an SRI is beneficial for patients with OCD who do not respond to SRI treatment alone.
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Quetiapine addition to serotonin reputake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study.Denys D, van Megen H, Westenberg H.
Department of Psychiatry, University Medical Center, Utrecht, The Netherlands. D.A.J.P.denys@azu.nl
OBJECTIVE: Although patients with obsessive-compulsive disorder (OCD) benefit from treatment with serotonin reuptake inhibitors (SRIs), it is estimated that 40% to 60% of the patients remain unimproved. The objective of this study was to examine whether addition of the atypical antipsychotic quetiapine to SRIs is useful for patients with OCD who do not respond to SRI monotherapy. METHOD: Ten patients with OCD (DSM-IV criteria) who had not responded to at least 3 previous treatments with an SRI at maximum dose and duration were assigned to receive quetiapine in addition to an SRI for 8 weeks. Treatment response was assessed using the Yale-Brown Obessive-Compulsive Scale (YBOCS). RESULTS: Seven of 10 patients responded to the quetiapine addition. The mean +/- SD baseline YBOCS score of 31.4 +/- 7.8 dropped to a mean of 20.8 +/- 8.4 at endpoint with a mean reduction of 35.4%. CONCLUSION: This is the first study to show that treatment-refractory OCD patients may benefit from addition of quetiapine to ongoing SRI therapy.
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Quetiapine augmentation in patients with treatment resistant obsessive-compulsive disorder: a single-blind, placebo-controlled study.Atmaca M, Kuloglu M, Tezcan E, Gecici O.
Firat University, Medical Faculty Hospital, Department of Psychiatry, Elazig, Turkey. matmaca_p@yahoo.com
Recently, atypical antipsychotics have been used for the management of the patients with refractory obsessive-compulsive disorder (OCD). The aim of the present study was to evaluate the results of quetiapine augmentation to a serotonin reuptake inhibitor (SRI) in the patients with refractory OCD. Fifty-two patients with OCD according to DSM-IV entered 3 months of an open-label phase treatment with a SRI with or without concomitant adjunctive treatment regimen. Of them, 27 patients were refractory OCD. These patients were randomly divided into two groups, SRI plus quetiapine and SRI plus placebo, for an 8-week single-blind phase. The course of OCD was evaluated by Yale-Brown Obsession-Compulsion (Y-BOCS) and Clinical Global Impression-Severity of Illness and Improvement (CGI-SI and I) Scales every other week for 8 weeks. Of the 14 patients in group I, nine (64.4%) showed significant improvement with 60% or greater improvement on the Y-BOCS and one (7.1%) partial improvement with 30% or greater improvement on the Y-BOCS, whereas no improvement was observed in group II. The addition of quetiapine to ongoing SRI therapy has been found to be effective and well-tolerated approach in patients with refractory OCD.
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Quetiapine augmentation of serotonin reuptake inhibitors in obsessive-compulsive disorder.Mohr N, Vythilingum B, Emsley RA, Stein DJ.
MRC Unit on Anxiety Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa.
The augmentation of serotonin reuptake inhibitors (SRIs) with atypical antipsychotics for the management of treatment-resistant obsessive-compulsive disorder (OCD) is gaining increasing acceptance. Quetiapine is a novel antipsychotic which is well tolerated, and which may therefore be particularly useful in this context. Charts of all patients treated in our OCD clinic with the combination of an SRI and quetiapine were reviewed. Demographic details and clinical symptoms on the Yale-Brown Obsessive-Compulsive Scale and the Clinical Global Impressions Scale (CGI) were tabulated before and after augmentation. Eight OCD patients who had proven resistance to treatment with SRIs had received quetiapine augmentation. Four of these eight patients were responders (CGI of 1 or 2) within 4 weeks. In the treatment-responders, the medication was well tolerated. Although limited by the retrospective design and lack of controls, these data are consistent with the growing literature suggesting that approximately one-half of OCD patients resistant to treatment with SRIs may respond to augmentation with an atypical antipsychotic. Quetiapine, a relatively well tolerated agent, deserves further controlled study in this context.
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Personal stories.............the good and the not so bad
My dose depended on the severity of anxiety I was experiencing and it was b/t 150-3oo daily.It was a great alternative to xanax-it helped w/ constant panic attacks and it was not addictive for me. Great for sleep!!! not for depression and not helpful in long term mood stabilizing no matter what the fda and info packets say. I had a year of experience with seroquel and it was helpful for the things mentioned. There is no generic and the $$ so you better be willing to pay bucks for this great sleeping pill. Dosage: 300 mg. tablet
Frequency: 1 tablet 1 x day
Total Length: one year
Brand: Seroquel
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Breezen
I do not take this med, but my husband does. He has a long history of mental illness. There has never been a clear diagnosis of his problems, but he has severe episodes of depression, anxiety and phychotic episodes. He has tried every med listed on this site practically and NOTHING has worked. Finally, a new doctor put him on serouquel. Before this time, my husband had not left the house for three years. He pretty much stayed home and watched TV and played on his computer. But after starting seroquel, he "got his life back", he now sits on a local chamber of commerce board, goes to a daily coffe group, and is out and about every day. He is a new and happy person again. We are thrilled.I don't know that this drug is for everyone, but for those who have given up hope, this maybe one to try. It really seems to help with severe anxiety. That was his big problem in leaving the house. It is listed for so many other purposes, but it can do so much more - we are big seroquel fans in our house!
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Seroquel Augment for Depression & Anxiety
This low dose has been very effective at augmenting my antidepressant remeron in my treatment resistant Major Depression. It has also helped immensely with my anxiety, insomnia, and dissociation associated with PTSD.I LOVE MY SEROQUEL.
Dosage: 25 mg. tablet
Frequency: 1 tablet 2 x day
Total Length: several months
Brand: Seroquel
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Life Saver
I don't know what I would do without Seroquel. I am unable to use anything else for anxiety, so this is all that works. My doctors have just been able to change my doses when my other meds change accordingly. It has been the only thing that has been a confortable constant in my life of forever changing variables!
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seroquel
it works for me! just started taking about a month ago. have GAD ..anxiety, insomnia (severe), irratability muscle tension, headaches, digestive problems, rapid heartbeat, sweating, nightmares...all the classic symptoms. have tried almost everything out there over the last 15 yrs some worked but not for long. also have depression. take effexor, xanax, & seroquel 75mg at bedtime. have been sleeping like a baby at nite. i hope this one lasts. Dosage: 25 mg. tablet
Frequency: 2 tablets 3 x day
Total Length: one month
Brand: Seroquel
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Hope this helps!!!Ace
poster:ace
thread:446148
URL: http://www.dr-bob.org/babble/20050119/msgs/446495.html