Posted by sdb on January 17, 2005, at 8:12:02
In reply to Inderal (propranolol hydrochloride) for anxiety??, posted by Impermanence on January 15, 2005, at 14:18:47
Propranolol: effective but tiredness, lethargie and betareceptor upregulation (less effective with time)
Oxprenolol (Slow version): very effective, because of ISA betareceptor downregulation, can cause sexual sideeffects
Pindolol: very effective and because of ISA no beta upregulation but sexual sideeffects, headache
Nadolol: very effective but tiredness, sexualsideffects
Bopindolol (not available in USA): very effective, elevate HDL, but some headache and some sexual sideeffects
Atenolol: less effective, unfortunately betareceptor upregulation, elevates LDLNot effective are primarely the beta1-selective.
The beta1-selective block mainly the noradrenaline of nervi cardiaci. The beta1-selective blocks the exercise tachycardia but less the tachycardia caused by isoprenaline or in anxiety situations the adrenaline released from adrenal medulla. There are many beta1-receptors on heart but there are also many beta2-receptors so the nonselective are more effective.Effective means it can reduce contractility force of heart and heart rate. Perhaps it helps against trembling. But it does not mean that you have less anxiety.
Unfortunately the effective unselective betablockers have more sideeffects because there are many beta2 receptors on other organs and the cardiovascular system.
poster:sdb
thread:442455
URL: http://www.dr-bob.org/babble/20050113/msgs/443075.html