Posted by lars1 on January 8, 2005, at 12:05:55
Have you taken both bupropion (Wellbutrin, Zyban) and methylphenidate (Ritalin, Concerta, Metadate), not necessarily at the same time? If so, how would you compare the effects? I ask because I currently take bupropion (for ADD and depression) and am wondering whether methylphenidate might work better for me.
Both bupropion and methylphenidate are dopamine/norepinephrine uptake inhibitors. Both are sometimes used to treat ADD. Both have mood-elevating properties. Bupropion has a long (21 hr) elimination half-life, while methylphenidate has a short (3 hr) one. Therefore, bupropion might be expected to have a smoother effect, with less tendency toward stimulant "crashing" as a dose wears off. On the other hand, the long half-life also means that bupropion remains in the body at high levels through the night, not just during the day. Therefore bupropion might be more likely to cause insomnia and more likely to "poop out" over time. Does any of this match your experience?
Lars
poster:lars1
thread:439402
URL: http://www.dr-bob.org/babble/20050108/msgs/439402.html