Posted by sdb on December 27, 2004, at 20:18:38
In reply to Re: Trazodone 50mg, OMG//sdb, posted by HappyGirl on December 27, 2004, at 19:06:41
Hi HappyGirl,
300mg of trazodone is higher starting dose.
Trazodone and Nefazodone have a similar chemical structure. Nefazodone
differs in the Pharmacokinetics, side effects and the transformation of the
liver. The two substances have a unique system to increase extracellular
serotonin levels. Trazodone increases the 5-HT extracellular level through a
double mechanism in which the 5-HT transporter and 5-HT 2A/C receptors are
involved and it has influence of GABA transmission. In the majority of cases
the antidepressive effect of serotonin inhibitors (ssris) start in about 30
days. Trazodone is said to work in seven or less days. The unique
pharmacological profile and the high starting dose could have triggered the
"jump-start". I suggest you to find a maintenance dosage by go down
gradually from the 300mg dosage.kind regards
sdb
poster:sdb
thread:433732
URL: http://www.dr-bob.org/babble/20041223/msgs/434758.html