Posted by rod on December 25, 2004, at 19:10:15
In reply to LYRICA, T3, Nicergoline, Pentoxifylline Experience, posted by rod on December 25, 2004, at 18:53:07
> Hi!
>
> Some weeks have passed since I announced I will begin my Lyrica trial. So far, I am having a positive experience with Lyrica, but limited due to my poly drug treatment.
> In general I can say that it has a stronger effect on social anxiety, although I would not call me a typical socialphobic. I dont have any physical signs of anxiety, and just general dont feel comfortable when there aur many people around me and dont talk want to much (and havent had any girlfreind the last 8 years :-( because of depression, anxiety. and no, I am not just ugly :-) ). Lyrica improved it from day 1 on, but the effect seems to wear off within some days, but a noticeable improvement still exists.
> 1 Week before starting Lyrica I added T3 thyroid hormone agumentation to my regimen, which also really improves my condition, especially cognition and concentration.
> One month after that I added "Nicergoline" (an ergot alkaloid), a vasoactive drug, which also increases catecholamine turnover, especially dopamine and blocks alpha adrenergic activity to some extend, increases protein synthesis inside the cells, increases glucose utilisation, oxygen concentration, increases vigilance etc. etc. It serves as a mild *psychostimulant* without causing depression or crash! Its really a great drug so far, for me... ! Also a a scavenger of free radicals etc. etc. Search at www.pubmed.org for details. This drug really does a *lot* in the body.
> And the second big hit for me is "Pentoxifylline". Also a vasoactive drug (available in the US under the brand name "trental"). monograph : http://www.rxlist.com/cgi/generic/pentox_cp.htm
> Its a little bit sedating, so I take it at night. Adding this drug to my cocktail further improves my mental status. Also this drug does quite a lot. search at pubmed if interested. It has immuno modulatory properties for example, has an antiinflammatory effect, etc. etc.
> Again, the experience is limited, because by now, the T3 augmentation should really "kick" in, according to my doc, which takes about a month or so.
> Anyway, after adding Nicergoline and Pentoxifylline my condition really improved very much! I also believe this is because of more blood, and so also more drug molecules reach the right spot, the brain. **They are very powerfull AD augmentors for me!** Increasing mental energy, concentration ,mood and also further reduce social anxiety.... I am fully satisfied with my drug treatment right at the moment. Now its time to do some therapy to restore my destroyed life....
>
> So if you suffer from cognitive impairment, which is unresponsive to the common drugs like Adrafinil, Ritalin, Aniracetam, piracetam, Reminyl, Exelon etc. (which all make me *worse*), you should give the vasoactive drugs a go. And I am "just" 25 years old.. I am glad I could convince my current doc to give these drugs a go, because he agreed that I might be after a "side effect" from some drugs. Amitriptyline for example is also a powerful vasodilator via multiple mechanisms... Many drugs also alter cerebral blood flow to some extend.... Most anticholinergis relax smooth muscle cells, which are also "wrapped" around the blood vessels, as far as I know.
>
>
> I am getting better week by week.... yay!! The extra blood in my head feeds my brain cells with nutritients, monamine precursors etc.. yummy :-)
>
> So now I take a load of tabs a day..
> nortriptyline 150mg
> amisulpride 50mg
> Lyrica 450mg (150mg three times a day)
> Clonazepam 0,375mg (want to get rid of this)
> T3 25ug
> Nicergoline 30mg
> Pentoxifylline XR 600mg
> Diphenhydramine 100mg
>
> And 3 cups of coffee a day is also part of my coctail. Its essential, also like Smoking. I tried to stop by using a nicotine inhaler, but nada, only attenuates nicotine craving and does nothing for my mood etc... guess its the MAO-B inhibitor in the tobaco smoke..
>
> And I hoping that this positive trend continues...
>
> wich me luck people :-)
>
> 'nuff said
>
> RolandAlso something interseting. I have antibody for the p-24 borna disease virus protein.
p-24 is probably linked to negative shizophrenia (dopamine deficit). My doc also thinks there is something wrong with my dopamine stuff in my head.
from http://www.neurotransmitter.net/bornavirus.html
-------Iwahashi K, Watanabe M, Nakamura K, Suwaki H, Nakaya T, Nakamura Y, Takahashi H, Ikuta K.
Positive and negative syndromes, and Borna disease virus infection in schizophrenia.
Neuropsychobiology. 1998;37(2):59-64.
"The relationship between Borna disease virus (BDV) infection and positive and negative syndromes in schizophrenia was investigated. By nested RT-PCR and Western blotting, BDV-specific RNA and anti-BDV antibodies were examined in blood from 67 schizophrenic patients (DSM-III-R) in Japan, and the psychometric properties of the Positive and Negative Syndrome Scale (PANSS) were analyzed. There were significant (p < 0.05) differences in the composite index denoting the positive minus negative difference indicating a dominant contribution by negative items, and the proportion of negative type (positive minus negative value below zero) patients, between patients positive and negative for anti-BDV p24 antibodies. It is possible that BDV infection with induction of BDV p24 antibodies may be associated with negative syndromes in schizophrenic patients." [Abstract]Waltrip RW 2nd, Buchanan RW, Carpenter WT Jr, Kirkpatrick B, Summerfelt A, Breier A, Rubin SA, Carbone KM.
Borna disease virus antibodies and the deficit syndrome of schizophrenia.
Schizophr Res. 1997 Feb 28;23(3):253-7.
"We detected anti-Borna disease virus (BDV) antibodies at a 14.4% rate in patients with schizophrenia. The hypothesis of a higher rate of BDV seropositivity in deficit syndrome was borne out in a subset of 64 patients categorized according to the Schedule for the Deficit Syndrome with 5/15 seropositive deficit and 4/49 seropositive nondeficit (p < 0.05). This suggests that the antibodies and possibly a BDV-like virus are pathogenetically linked to this form of schizophrenia." [Abstract]-------------
Last sentence : "..This suggests that the antibodies and possibly a BDV-****like*** virus are pathogenetically linked to this form of schizophrenia
On th long term, Amantadinte, does nothing good for me. But maybe its inefficient for Borna... because its just a yet unidentified Borna-like virus.... who knows...
And then I found this one:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8284924
(reminder: Trental = Pentoxifylline)
----------Vopr Virusol. 1993 Sep-Dec;38(5):230-3. Related Articles, Links
[New properties of trental as an inhibitor of viral activity with a wide range of activity]
[Article in Russian]
Amvros'eva TV, Votiakov VI, Andreeva OT, Vladyko GV, Nikolaeva SN, Orlova SV, Azarova IA, Zgirovskaia AA.
Experimental investigations on the spectrum and degree of the expression of trental antiviral activity were carried out. The investigations were done in cell cultures and laboratory animals using laboratory strains (including drug-resistant ones) of 13 viruses, causative agents of human and animal infections. The drug demonstrated its activity against 8 viruses of 7 families. It was highly active against 5 viruses: herpes simplex virus (including its acyclovir-resistant strain), vaccinia virus (including its methisazone-resistant strain), rotavirus and tick-borne encephalitis virus. As regards other viruses, its activity was less pronounced (hepatitis JA virus) or low (vesicular stomatitis virus, West Nile virus). It was concluded that, being a cardiovascular drug, trental was an effective broad spectrum virus inhibitor.
PMID: 8284924 [PubMed - indexed for MEDLINE]
------------
Thats a "wild" theory, but it is indeed possible it helps me, because of its antiviral activity....
poster:rod
thread:434128
URL: http://www.dr-bob.org/babble/20041223/msgs/434137.html