Posted by cache-monkey on December 20, 2004, at 13:27:59
Hey folks,
I started BuSpar a while ago and I've never been quite clear as to what it's doing for me. I feel like certain cognitive aspects of my anxiety/depression have been a little diminished, although my response to low doses of Lamictal so far trump even that.
But I feel that BuSpar might also be increasing other aspects of my anxiety. Particularly the physical ones (e.g. heart palpatations, tightness in my head/chest, etc.). Anyone else experience this?
Also, I'm wondering if this has anything to do with the alpha-2 andrenoreceptor antagonism of 1-PP, the primary buspirone metabolite. I don't really know what alpha-2 antagonism does, but I'm pretty sure that I don't react well to things that mess with my NE system. Also, I'm an intermediate to poor in my CYP-2D6 metabolism. Since 2D6 is responsible for clearance of 1-PP, maybe I've got too much of the 1-PP in my system. Any thoughts on this idea?
Thanks,
cache-monkey
poster:cache-monkey
thread:432065
URL: http://www.dr-bob.org/babble/20041217/msgs/432065.html