Posted by Nagash on December 14, 2004, at 8:21:46
In reply to Re: Time to act, at last... ?, posted by dove on December 13, 2004, at 9:33:20
> While Mianserin (Lerivon/Bolvidon) helped with
> your anxiety and sleep problems, did it agitate
> your Restless Legs Syndrome? If not, then mySort of.
> first recommendation is to try Remeron
> (generic-mirtazapine) before bed. At lower
> doses it is more sleep enhancing, at higher
> doses (45 mgs.) it is more activating and has
> more norepinephrine releasing properties (while
> still being a great sleep enhancer). Combine
> with Reboxetine or a more activating TCA
> (Nortriptyline, desipramine).
Remeron is too god damn expensive for what it offers, I guess. And if it also makes me sleep for 10h with additional 2 hours of being a zombie, then it's a no-no.> How much amphetamine are you taking daily? And
> are you ingesting it (rather than "tweaking" or
> "spinning")? There are some strategies for
> lowering tolerance and getting the most out of
> amphetamine's synergies. Be aware thatHard to say as it's black market. I usually take it sublingually, I'd say 30-50mg daily but purity can be anywhere from 60 to 80% here.
I take 1g Magnesium+B6, 15mg DXM to prevent rapid tolerance development and 1200mg Tyrosine daily to help replenish my dopamine.
> amphetamine can cause a worsening of depression
> as well as complicating its treatment (in
> addition to causing ambivalence to pleasurable > activates at higher doses.).I am perfectly aware of that and I am sure I want to quit this drug. As soon as I find a substitute I'll sacrifice those 2 or 3 days of moodines during the withdrawal. Or I might try tapering down.
> Cymbalta's generic name is duloxetine, a dual
> reuptake inhibitor, and definitely worth
> looking into.Not registered here ;( I see it costs $100 for a month's treatment, plus all the unreliableness of an international supply, I think this might be too much hassle for something which has a profile similar to venlafaxine, which didn't work for me, except for producing terrible withdrawals.
> Personally, I would try a combo of an
> activating AD, whether a TCA, SSRI, or SNRI
> with Remeron (mirtazapine) or Mianserin
> (Lerivon/Bolvidon). If I was going the
> Wellbutrin (bupropion) route, I would try that
> alone for a few weeks before adding anything
> else. I would also add a CNS stimulant to the
> first combo, but in small amounts and after a
> few weeks in order to adjust properly.Well, I strongly believe that my anxiety is somehow linked to my motivation. If I am at ease, I am more motivated. GHB did wonders for me, I will give Phenibut a try now.
> I am currently on Effexor 225 mg, Prozac 20 mg,
> Adderall 40 mg (20, 10, 10), Remeron 45 mg
> (before bed) with 2 mg of sublingual Melatonin.
> I have also taken klonopin with this combo for
> panic attacks and severe anxiety but haven't
> needed it at all for many (5) months.This is an impressive cocktail. I would really prefer to stick to 1 or 2 meds, for several reasons.
> One other med I still think is worth looking at
> is the MAOI Parnate, although it has some food
> and med interactions that would need to be
> taken seriously. Parnate and Cymbalta
> (duloxetine) are the two meds I have in mind
> should my combo begin to fail. However, I
> suffer from severe major depression. Lexapro
> might be something to consider, especially in
> combo with mirtazapine or mianserin.I've heard good things about Parnate but it's not registered either :( I can see you have a lot of experience with prescription drugs, mine are smaller and, thus far, mostly negative. This is why I want to evaluate dopaminergic and GABAergic drugs. Especially since both ease up my RLS, so there may exist a link...
> just some thoughts...
Thanks for your input.
poster:Nagash
thread:399975
URL: http://www.dr-bob.org/babble/20041211/msgs/429353.html