Posted by ed_uk on December 12, 2004, at 19:16:01
In reply to Re: To Tom, posted by ed_uk on December 12, 2004, at 18:28:00
To illustrate my point that it is very important to avoid the use of excessive doses of neuroleptics I thought I'd post this little abstract.....
Arzneimittelforschung. 1978;28(9):1491-2.
[Dose-effect relations. Doubleblind study on two different doses of pimozide (author's transl)]
[Article in German]
Fleischhauer J.
Two identical groups of schizophrenic patients were treated for 28 days randomized with 3 and 8 mg of pimozide. In the antipsychotic efficacy no difference could be seen. Difference was in side effects: The 8-mg group had three times more extrapyramidal signs, mostly akathisia and agitation, and needed seven times more minor tranquilizer than the 3-mg group. Severe agitation as a psychotic symptom was equal in both groups. Preference therefore is given to the smaller dosage.
NB. The potency of pimozide is similar to haloperidol.
poster:ed_uk
thread:427750
URL: http://www.dr-bob.org/babble/20041211/msgs/428516.html