Posted by Cairo on December 5, 2004, at 9:44:24
In reply to Zofran and anxiety, posted by ed_uk on December 4, 2004, at 18:00:52
I've tried Zofran for Fibromyalgia which includes depression and anxiety, but with no success for either pain, anxiety or depression. I remember reading somewhere that only 50% responded to ondansetron in a trial study for Fibromyalgia. Only my pocketbook had a favorable outcome as I was able to get ahold of samples instead of mortgaging my house to pay for it.
Here's a brief search on PubMed, though:
Olivier B, van Wijngaarden I, Soudijn W.
5-HT(3) receptor antagonists and anxiety; a preclinical and clinical review.
Eur Neuropsychopharmacol. 2000 Mar;10(2):77-95.
"Compared to the established anxiolytics (benzodiazepine receptor agonists and, to a lesser extent, 5-HT(1A) receptor agonists) 5-HT(3) receptor antagonists display a different anxiolytic profile. They are anxiolytic in a limited number of animal anxiety models. If active, they often are very potent and display bell-shaped dose response curves, whereas the ratio between therapeutic activity and side effects appears remarkably large. 5-HT(3) receptor antagonists remain active after chronic dosing and no indications for tolerance, dependence or rebound effects were found, which seems to make these drugs an attractive alternative to the benzodiazepines. However, the large body of animal data indicating a complete lack of psychotropic activity of 5-HT(3) receptor antagonists weakens the prediction of anxiolytic activity in these drugs."
Costall B, Naylor RJ.
Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):27-37
"5-HT(3) receptor antagonists seem to be of limited use in psychiatric disorders: where effects have been seen, they seem to be unusually sensitive to dose and stage of disease."