Posted by paulbwell on December 1, 2004, at 15:50:30
In reply to Re: HELP: DOC TAKES MY KLONO GIVES ME XANAX, posted by Paul Smith on December 1, 2004, at 14:18:08
> I hope you don't mind me giving an answer to your question. BTW, I am not from the UK. I have just done alot of research and talk with alot of experts on benzo addiction and use.
>
>
> There have been studies that have shown that
> certain benzodiazepines have a higher binding
> affinity to these receptors than others.
> Binding affinity refers to how tightly a given
> substance will bind to a corresponding
> receptor. All of these drugs do have in fact a
> fairly high binding affinity for these
> receptors. Anyway Valium has a fairly high
> binding affinity as compared to others in its
> class, while drugs such as klonopin, xanax, and
> ativan have extremely high binding affinities
> for the benzodiazepine receptor. This is what
> makes them so addictive. It is also why these
> drugs come in lower doses than valium. It is
> because they are higher in potency and less of
> the drug is needed to achieve a therapeutic
> effect.
>
> Thanks for answering. :-) I will ad that i have taken several different benzos and found them interchangeable.
>Thanks JackJ,
But I know this already, the different dosages and binding capabilities of the said benzos. But my worry was, I know Clonazapam, being a longer acting Benzo, will often not show any significant withdrawal symptoms for days, or longer, then bang. My concern was with the substantially lower dose of Alprazolam, (and It's different, If any, binding capabilities to the Gaba receptors) being given to me, with It being of similar strength to Klono, and what effect, if any, this may have.
Paul Smith
Hi paul, I would like to know If you have switched these two said Benzos, and what doses of different benzos you have taken, after each other.Do I need to worry? after all Xanax is the leading Anxiety Med, and maybe it would be just as effective as my previous higher dose of Klono at a lower dose?
and with the coverage of the Imipramine, perhaps that will help? and do more than just make me gain 6kgs in one month!Cheers JackJ and Paul
poster:paulbwell
thread:422585
URL: http://www.dr-bob.org/babble/20041201/msgs/422970.html