Posted by Pluto on November 29, 2004, at 0:58:50
In reply to Re: PLUTO: SULPIRIDE timing and dosage. » Pluto, posted by Iansf on November 29, 2004, at 0:13:19
Hi Dear,
Good question. First of all amisulpride, sulpiride and flupenthixol (Fluanxol) are not first line antidepressants. (Interestingly these drugs are not available in U.S) When other antidepressants fail or patients find it hard to tolerate their side effects, docs use these drugs as alternatives. And unlike traditional antidepressants, amisulpride, sulpiride and flupenthixol exert their efficacy within a few days or I would say within hours. It is because they target Dopamine receptors in the brain to stimulate them indirectly to create a mood elevation. For instance I can feel the anxiolytic effect of sulpiride within hours after taking it along with a lift in mood. But for unknown reasons I don't feel the initial high to be long lasting, but anxiolysis remains plusa mild alerting or call it antidepressant effect. I have been taking it for a long time, and can confirm the antidepressant effect is gradually declining. I would say, sulpiride would rather be an anxiolytic. An effective anxiolytic, and a mild antidepressant.
Amisulpride on the other hand is more potent than sulpiride hence is more of an Antidepressant. I haven't used it, so can't comment.
Flupenthixol in doses lower than 3 mg is having an activating effect. It is similar to those of sulpiride and perhaps amisulpride. But once again the mood elevation was short lived, and most importanly it triggered another episode of major depression in me after using it over a month or so in the past. Luckily sulpiride is not doing the same, and I hope never will.
Cheers
poster:Pluto
thread:419791
URL: http://www.dr-bob.org/babble/20041128/msgs/421674.html