Posted by Cairo on October 27, 2004, at 5:39:11
In reply to Re: Norepinephrine and anxiety, posted by Cecilia on October 27, 2004, at 1:58:03
I'm finishing week 3 of Cymbalta and the agitation/jumpiness is becoming too much to handle. I don't feel particularly "anxious", just physical symptoms such as shaking, insomnia, hypersensitive to sounds/light/stimulus, stiff neck, elevated BP (start to notice at 30mg), stomach pain, hot flushes, blurry vision, decreased appetite, and increased energy (the only two positive things, though the energy manifests itself as the need to run around and clean, almost like too much caffeine). I started Cymbalta at 30mg and had to lower it to 20mg then to 10mg. Things actually seem to be getting worse maybe because it is disrupting my sleep and increasing pain (I have Fibromyalgia and Myofascial Pain). Yesterday I was sitting in the car waiting for my daughter when an acorn fell from a tree and hit the top of the car - I literally almost hit the ceiling and felt like I was going to burst into tears. Even the vibration from driving down the road seems amplified and makes me feel like I'm going to jump out of my skin. My neck muscles are unbelievable tight and my jaw often feels like it's trembling. I react terrribly to SSRI's and me thinks even with a balanced SSRI/NRI effect it's too much.
I've got an appointment with my Pdoc in two weeks, but I don't know if I can continue with Cymbalta until then. Do you think these SE will go away or should I just give it up? The other day I forgot to take my 10mg and it was the best day I've had in 3 weeks. I tried cutting down on the Desyrel I take for sleep (from 100mg to 50mg) in case the Cytochrome P450 enzyme 2DP competition was increasing the blood levels of Cymbalta, but then I don't sleep and that is awful for my Fibro symptoms. What do you think?
Cairo
> I don`t understand how drugs that increase norepinephrine can NOT increase anxiey, though obviously for a lot of people they don`t. Cymbalta definitely increased my anxiety, though not as bad as Effexor, though nothing in the world could be as bad as Effexor. Well, no Parnate was. Cymbalta didn`t make me sleepy, but I sure know that tired but wired feeling you mentioned, Zynhymer, Remeron gave me that, that feeling of being totally exhausted but at the same time ready to jump out of your skin-it`s a horrible feeling. Cecilia
poster:Cairo
thread:406395
URL: http://www.dr-bob.org/babble/20041024/msgs/407788.html