Posted by karaS on October 16, 2004, at 14:52:32
In reply to Re: Parnate Experience » karaS, posted by King Vultan on October 11, 2004, at 9:36:12
> I don't think there's necessarily anything terribly wrong with my NE system because I responded to desipramine and protriptyline exactly as one is supposed to, and these are selective NE reuptake inhibitors. I know I do have hypersensitive alpha-1 adrenergic receptors, but I'm not sure how much this really matters. I suppose it could have something to do with the strange effect the Provigil had on me, though.
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> As far as the hypersensitive dopamine autoreceptors, based on my anhedonia, low libido, ADD symptoms, etc., my dopamine system does appear to operate at a chronically low level, and considering my reactions to various drugs, it's as good a hypothesis as any. I'm not an MD or a PhD researcher, but I question the notion of not being able to downregulate dopamine autoreceptors. I don't quite understand why the heck that would be. Also, keep in mind that two people with the same general condition may have it expressed in different ways or differ in some intricacies. There are four separate dopamine pathways in the brain, and these are interconnected with a myriad of other stuff. It does not seem reasonable to expect that everyone with hypersensitive dopamine autoreceptors would react to every medication the same way; although, one would hope there might be some similarities. From what you've said, you do appear to be more likely to have hypersensitive dopamine autoreceptors than I do.
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> ToddThanks Todd for answering my question so adeptly. What you said makes a lot of sense. I think that my next move should be to do some serious research in this area. The other thought I had this week was that perhaps noradrenergics can compensate for some of the problems of low dopamine. OR, maybe the naturally increased NE can increase DA in a way that doesn't elicit too much overresponse from the autoreceptors. Sounds crazy I know but the reason I'm suggesting this is because of my experience this week. I was very busy working. The adrenaline was flowing and I felt good - more energized, motivated and happy (without feeling overly stressed-out) than I have in a long time. Does this make any sense at all to you? Any thoughts would be appreciated.
Kara
poster:karaS
thread:400754
URL: http://www.dr-bob.org/babble/20041012/msgs/403862.html