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Re: Cymbalta @ 2 Weeks

Posted by hawkeye on October 8, 2004, at 23:11:28

In reply to Cymbalta @ 2 Weeks, posted by RunawayAmericanDream on October 8, 2004, at 14:32:48

You are probably getting a much larger dose of Cymbalta than you realize.

Wellbutrin is a potent inhibitor of the CYP2D6 enzyme.

According to the PDR for Cymbalta: "Because CYP2D6 is involved in duloxetine [Cymbalta] metabolism, concomitant use of duloxetine with potent inhibitors of CYP2D6 may result in higher concentrations of duloxetine."

In short, if you take Wellbutrin and Cymbalta together you could be getting a MUCH HIGHER dose of Cymbalta than indicated from the specifications for the Cymbalta capsule.

I took the two together for a short period of time but got severe sexual side-effects. I then stopped taking the Wellbutrin and continued with the Cymbalta (40mgs/day) and the side-effects almost went away completely.


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poster:hawkeye thread:400464
URL: http://www.dr-bob.org/babble/20041007/msgs/400627.html