Posted by Rick on October 1, 2004, at 2:53:32
In reply to Re: klono provigil-any magnification when combini » Waki, posted by alesta on September 29, 2004, at 23:11:13
> hi, wak! thanks! the provigil wakes you up but without producing anxiety like the stimulants do..that's one thing that's so great about it (among many).
I agree completely. Been on 1 mg/day Klonopin + 100mg/day Provigil, for 4 years now for severe, non-depressive generalized social phobia. Once in awhile 100 mg Provigil doesn't seem to do the trick wakefulness-wise, but that's very much the exception to the rule for me.
> > The only thing you may want to watch is to make sure the provigil does not cancle out the klon.
>
> i definitely will, and will increase my klon dose if necessary..good to hear from you, man! :)
>I've had no need to increase my Klonopin dose when I added Provigil. A few posts above, it was suggested that Provigil induces Klonopin metabolism, i.e. lowers Klonopin blood levels. But, unless there's been some recent new evidence, I don't believe it works that way.
Animal research shows that Provigil can indeed speed up metabolism of drugs that are substrates of liver enzyme CYP3A4 *and also have significant first-pass metaolism in the gut* (e.g., Halcion). While Klonopin is indeed a substrate of CYP3A4, it doesn't undergo first-pass metabolism, and thus would not have a metabolic interaction with Provigil.
As always, YMMV.
Rick
poster:Rick
thread:396313
URL: http://www.dr-bob.org/babble/20040927/msgs/397744.html