Posted by zeugma on September 30, 2004, at 18:35:36
In reply to Re: why does Provigil help my ADD, posted by jlbl2l on September 30, 2004, at 17:43:52
> provigil is a mild stimulant. it increases extraxellular dopamine.
yes I know but Ritalin also increases extracellular dopamine. provigil has some actions that are unique to it, in that it operates on the GABA and glutamate systems. For instance in the abstract I quoted it inhibited GABA release in the striato-pallidal region, which would mean that there would be less inhibitory neurotransmitter in the region of the brain most directly associated with motor output (GABA is the major inhibitory transmitter in the brain). It is these other actions of Provigil that are associated with its therapeutic effects for me. Notably, too, I developed tolerance to the stimulating effects of Ritalin very rapidly, but tolerance did not develop with Provigil, and I suspect that I am not unique in this respect.
In any case, I called my pdoc and told him about my idea to add back Strattera. he told me to take about 20 mg of Strat with the Ritalin in the morning. i will be reporting soon on the effects of this addition.
-z
poster:zeugma
thread:397388
URL: http://www.dr-bob.org/babble/20040927/msgs/397414.html