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i have refs., and they support AD effects » Dave001

Posted by chemist on September 28, 2004, at 1:48:00

In reply to Re: They wont give me Xanax » Fred23, posted by Dave001 on September 27, 2004, at 14:20:23

> > Klonopin has a reputation for causing or accentuating depression
>
> Do you have any references to support that claim?
>
> Dave

hello there, chemist here...i have the following citations from pubmed...i do believe evidence is scant supporting the claim that clonazepam induces depression or, at worst does nothing. all signs point to antidepressant activity of clonazepam. on another note, hi fred, good to see you again! best, chemist

A Case of ``Double'' Depression under Outpatient Treatment Conditions. Ros, LT. World J. Biol Psychiatry. 5(3):161-163 (2004).

(from abstract): studied major depression with psychic depressive attacks. N = 1 (yes, one patient). sertraline 100 mg qd, clonazepam 1 mg a.m., 1 mg noon, 2 mg in evening (4 mg total) and titration on tegretol from 200 mg to 400 mg, qd in evening. complete remission of major depression and complete remission of dysthymic attacks of ``temporal epilepsy'' were obtained.

Clonazepam as a therapeutic adjunct to improve the management of depression. Morishita, S. Nihon Shinkei Seishin Yakurigaku Zasshi. 24(2):75-78 (2004).

(from abstract): The effect of clonazepam on depression was first reported by Jones and Chouinard in 1985. Since their report, many other investigators have reported on the antidepressant properties of clonazepam. A daily dose of at least 3.0 mg clonazepam in augmentation of ongoing antidepressant treatment should be considered in depression.

A case of marital discord and secondary depression with attempted suicide resulting from REM sleep behavior in a 35-year-old woman. Yeh, SB and Schenck, CH. Sleep Med. 5(2):151-154 (2004).

(from abstract): 35 yr. old female w/childhood-onset parasomnia developed marital discord due to disruption of husband's sleep. Separate bedrooms led to depression then acute suicidal behavior. No psychiatric history prior to marriage. Confirmed idiopathic sleep behavior disorder (RBD). Treatment with clonazepam, 1.0-1.5 mg hs controlled her RBD, moved back into bedroom, which fully resolved their marital discord and her secondary depression.

Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder. Winkler, D. et al. Eur. Neuropsychopharmacol. 13(2):129-134 (2003).

(from abstract): Patients with unipolar depression had significantly (P=0.026) less depressive episodes after initiation of treatment with clonazepam. Patients with bipolar disorder did not benefit from this therapy. Interestingly, clonazepam also reduced affective phasess in our 4 schizoaffective patients on a trend level. Our results indicate that patients with unipolar depression may benefit from a maintenance treatment with clonazepam.

Clonazepam augmentation of antidepressants: does it distinguish unipolar from bipolar depression? Morishita, S. and Aoki, S. J. Affect. Disord. 71(1-3):217-220 (2002).

(from abstract): N = 38, 1:1 unipolar:bipolar. 3.0 mg clonazepam/day for 4 weeks. In the unipolar depression group, 84.2% of the subjects fulfilled the response criteria (at least an 80% reduction in their HDRS score). However, in the bipolar depression group, only 10.5% of them fulfilled these criteria. CONCLUSIONS: ...clonazepam can play an active role in the treatment of protracted depression in patients with unipolar depression. LIMITATIONS: open study, and effect on clonazepam alone was not established.

Clonazepam inthe treatment of protracted depression: a hundred-case report. Morishita, S. Nihon Shinkei Seishin Yakurigaku Zasshi 22(3):97-101 (2002).

(from abstract): N = 100 depressed patients. assess use of clonazepam as adjunct for treating protracted depression. 3 mg/day expressed high effectiveness (78.4%) on prtracted depression. same trend in re: less effective in bipolar observed. Continuation of clonazepam after improvement disturbed the recurrence of depression, and it seems that clonazepam augmentation has a preventive effect.

...and a whole lot more. go to pubmed, keywords clonazepam and depression....


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