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Re: Moclobemide/Manerix vs. Nardil

Posted by King Vultan on September 21, 2004, at 12:54:50

In reply to Moclobemide/Manerix vs. Nardil, posted by maddog on September 20, 2004, at 20:55:36

> Hi Everyone,
>
> I met with a new pdoc today who suggested that I try Manerix (a reversible MAOI) instead of Nardil. I have seen little written about Manerix in terms of its side effects and efficacy, especially with respect to anxiety.
>
> Does anyone out there have experience with Manerix and can compare it to Nardil?
>
> thanks!
> maddog

In "Clinical Advances in Monoamine Oxidase Inhibitor Therapies", there's a chart listing moclobemide side effects vs. amitriptyline and placebo. Moclobemide side effects were nearly identical to placebo in some cases, such as dry mouth and sedation, less than placebo in a couple (constipation and tachycardia), but significantly more than placebo in insomnia (~18% vs. ~2%) and gastrointestinal discomfort (~39% vs. 20%). Amitriptyline had brutal dry mouth (~96% vs. <20% on both moclobemide and placebo) and was signficantly more sedating, at about 53% versus about 16% for both placebo and moclobemide.

Todd


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poster:King Vultan thread:393164
URL: http://www.dr-bob.org/babble/20040921/msgs/393362.html