Posted by SLS on September 19, 2004, at 7:26:31
In reply to Re: To SLS » SLS, posted by zeugma on September 17, 2004, at 19:37:33
Hi Zeugma.
Sorry about the lateness of this reply.
> Do you think that desipramine has memantine-like antitolerance effects?
I wouldn't think so. The effects of memantine might be mediated through the modulation of neuroplasticity via blockade of NMDA receptors and the resulting reduction of glutamatergic neurotransmission.
> I suppose nortriptyline would be similar? In any case I will definitely investigate memantine in the next few months. How would you characterize its effect on you?
I began taking memantine 20mg while I was already taking imipramine 300mg and Lamictal 300mg. I experienced an unequivicol antidepressant response within the first few weeks. It lasted for less than a week. I have continued with it because it has allowed me to reduce the dosage of Lamictal to 150mg, thus reducing the adverse cognitive side effects it was producing. Also, I was hoping it might help make Cymbalta "stick" in a fashion similar to an antitolerance effect. Of course, I have no scientific evidence that this should happen, but I don't think it could hurt.
I remember quite clearly the experience of one poster who added memantine to Adderall. Prior to adding it, it was necessary for him to cycle on and off Adderall every three or four days in order to recapture its stimulant/antidepressant effect. Upon adding memantine, this was no longer necessary. He was able to take Adderall continuously, and described a "smoother" response to it.
- Scott
poster:SLS
thread:391304
URL: http://www.dr-bob.org/babble/20040915/msgs/392536.html