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Re: Cymbalta honeymoon is over » steve12

Posted by alesta on September 16, 2004, at 12:14:42

In reply to Re: Cymbalta honeymoon is over, posted by steve12 on September 16, 2004, at 11:35:36

> I think 5HT is involved in anxiety -- certainly for most people, paxil, prozac, etc relieve anxiety.

well, i have already explained why i think SSRIs are mostly helpful for some for anxiety. emotional numbness..don't feel pleasure, pain, anxiety, etc.

<I would agree that dopamine stimulation is underused in depression -- but for a different reason. Thers is emerging evidence that chronic administration of SSRI's may downregulate DA receptors, which may account for the cognitive fuzzieness that many depressives report.
>
> I think that NE (and cymbalta's re-uptake of it) is repsonsible for the anxiety that many experience. But that's just my 2 cents :)

so you're saying that the main neurotransmitters involved with anxiety are serotonin and norepinephrine? you are discounting lots of current research on the importance of dopamine and gaba.

and concerning norepinephrine's role in anxiety, i have compared the success rate of effexor and the success rate of prozac (an SSRI) for anxiety, and it was *exactly that same*. if norepinephrine played a significant role then you would expect the success rate to increase with effexor. but i admittedly am still unsure about norepinephrine...

amy


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poster:alesta thread:390747
URL: http://www.dr-bob.org/babble/20040915/msgs/391504.html