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Re: Should I try Cymbalta? JonW? / DA-antags + D-amp? » Ame Sans Vie

Posted by jparsell82` on September 10, 2004, at 13:34:40

In reply to Should I try Cymbalta? JonW? / DA-antags + D-amp?, posted by Ame Sans Vie on September 7, 2004, at 16:58:01

I just wanted to add in that I was contemplating trying a similar thing. I was going to try out a D2 antagonist such as Seroquel combined with Deprenyl to see if I would get benefits from increased output at D1,especially D3,D4, and D5 receptor sites.

> Hi everyone,
>
> First, as this is the first time I've had access to a functional computer in four days, let me just express my frustration here in this public forum to get that over with: I HATE WINDOWS XP. I HATE MICROSOFT. Okay... feeling better. :-)
>
> The latest news: I see my pdoc tomorrow, which would mark my 28th day on 200mg desipramine, but I think I'd better skip that twenty-eighth dose. It may have exerted some mildly beneficial effects on my mood, but the recent development of heart palpitations seems to warrant a second look at whether this stuff is really worth it, and I think not.
>
> JonW, I hope you don't mind -- I put your name in the subject line because I read above about your experience thusfar with Cymbalta. That's great! What's especially striking to me is the way you described your syndrome as the sort of anxiety/depression combination that allows for all sorts of labels. My three main problems, too, are atypical depression, social phobia and ADD. So, this is addressed to you and anyone else who wants to throw in their opinions: I've had the anxiety, impulsivity, inattention, anergia and amotivation under control for some time now with Klonopin (12mg) and Adderall (120mg); amphetamine tolerance has been halted with Dexalone (60mg); the depression is largely eradicated, and truth be told, I could "get by" quite well just on my current med combo, but I would mind neither the possibility of extra relief from Cymbalta nor the possibility of reducing other medication dosages by adding on this medication. I only have a few questions:
>
> 1. Mostly for JonW -- would it be possible for you to draw a comparison in a bit more detail for me between Paxil and Cymbalta? I'm all too familiar with the former, and it would certainly help me to come to my final decision about tomorrow.
>
> 2. Are others noticing effects from Cymbalta this early in treatment? I mean, I've read that it appears to be rapid-acting when compared to other ADs, but I was thinking that was just Lilly propaganda... can't help being a skeptic at this point. :-)
>
> 3. What are the side effects people are experiencing? I'm not so much concerned with sexual side effects, as Adderall works quite nicely to reverse that. But what about, for example, the emotional blunting so often attributed to Paxil and Luvox?
>
> The second part of my post is something I've wondered these past few days and it's been driving me *insane* that I wasn't able to post it here, lol. Going by my past reaction to Mirapex and my current response to amphetamines, I'm thinking that, at least in my case, some deficiency in dopamine transmission accounts for the pathology of quite a few of my problems. I'm wondering if, by using, for example, a D2 dopamine receptor antagonist like risperidone (yes, I know it also antagonizes 5HT2) would cause increased dopaminergic transmission at other DA receptor sites (i.e., D1, D3, D4 and D5) when taken along with amphetamines... ? Or, for that matter, what about a selective DA agonist? After all, both types of drugs occupy DA receptors, which is the basis of my hypothesis that enhanced transmission elsewhere would result. Or am I entirely on the wrong track? And if this *does* in fact make sense, which drugs would you assume to be better first-line choices for this purpose? I'm currently thinking primarily of Risperdal, Abilify, BuSpar, Mirapex and Requip.
>
> I know I'm asking for a lot of help in this post, so I just want to say in advance that I really appreciate absolutely *any* input! I'm a bit frazzled about what I should do tomorrow. :-\
>
> ~Michael


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poster:jparsell82` thread:387737
URL: http://www.dr-bob.org/babble/20040909/msgs/389237.html