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Re: To owensmar others

Posted by iris2 on September 5, 2004, at 14:16:48

In reply to Re: To owensmar others » iris2, posted by 4WD on September 4, 2004, at 21:47:03

Marsha,


Thanks.

I red several posts from you and to you and found my own questions answered thanks again. I also found we have a lot in commen. I take oxycontin ( a small amount) to be able to gain some pleasure/motivation to do every day tasks.

We seem to be looking at the same medications for similar reasons. I saw Mirapex was one suggested, I have thought of trying that.

"Anhedonia is such a severe problelm for me. I feel that my life is wasting away while I sit on the couch, unable to find pleasure or reward in anything at all"

"If I could experience pleasure normal, everyday life, well then, I'd actually have a life-instead of an existence"

I agree with all the above.

I thought I read you mention being bulimic, I am.

Did you get the answers you were looking for pertaining to Amisulpride?

Amisulpride, a selective antagonist for D2 and D3 dopamine receptors, acts preferentially on presynaptic receptors increasing dopaminergic transmission at low doses.

At low doses (100mg/day), amisulpride enhances
dopamine transmission by selectively binding to
presynaptic autoreceptors, contributing to its efficacy
in primarily negative symptoms.

Christine wrote: "...Amisulpride which is also an antagonist of Dopamines D2/D3 receptors. But at the dose I am taking (very low) it has more affinity to presynaptic receptors (called autoreceptors). If these are blocked then the release of Dopamine gets ENHANCED.

I take it for depression and it helps some.

What medication have you decided to try?

You were thinking of Cymbalta last I read.

I had inquired if you thought I should first try Milnacipran or Cymbalta? What do you think?

irene


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poster:iris2 thread:378449
URL: http://www.dr-bob.org/babble/20040904/msgs/386741.html