Psycho-Babble Medication | about biological treatments | Framed
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Re: Question for SLS

Posted by SLS on September 1, 2004, at 6:57:53

In reply to Question for SLS, posted by linkadge on August 31, 2004, at 20:23:42

Hi Linkadge.

> You mentioned that you get a rebound improvement whenever you quit a tryciclic. What do you think contributes to this ?,

The best I can come up with is that it has to do with changes in receptor sensitivity. My guess is that it is NE related, as this only happens to me with TCAs and MAOIs, and not SSRIs.

> I get rebound improvement when I quit antidepressants. I start to get messages that I was better off without them. Then I feel like god was trying to tell me something. Then, about 3 weeks later I'm really depressed and mildly psychotic.

That's about right. My post-discontinuation improvement lasts for about 2-3 weeks before I experience a noticeable deterioration.

> But I certainly do feel a transient sence of freedom and emotional improvement, it always fades however. I have been trying to figure out the mechanisms for this.

So, you experience this with SSRIs too? How would you compare your experiences with Effexor? What about TCAs?

Transient discontinuation rebound improvements (or even improvements upon dosage reduction) with TCAs have been reported numerous times in the literature. I don't see them with SSRIs.

- Scott




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