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Re: Need advise NOW!!! Nortryptiline + Nardil SLS

Posted by SLS on September 1, 2004, at 6:40:34

In reply to Re: Need advise NOW!!! Nortryptiline + Nardil SLS, posted by ace on August 31, 2004, at 21:57:24

Hi Ace.

> Studies have show combine with Clomipramine Nortriptyline produces more of a robust anti-OCD effect than Clomipramine alone.

That's fascinating. Psychopharmacology can be so cool sometimes.

> I started on 25mg last night- felt nothing, no adverse effects, nothing. But my doc believes we will have to push it up to 75mg for an adequate trial...have you got any suggestions?

No. I think you have everything well under control. You may want to use orthostatic hypotension as a guide as to how quickly you raise the dosage of nortriptyline. I wouldn't push too hard if you are having trouble standing up. :-)

I wish you luck. I think this combination is very worth your while to try. Just be on the alert for muscle rigidity/dystonia and altered mental status, as these were the symptoms of SS that first emerged when I tried combining the two drugs.

I'm not a cheerleader for Risperdal, but I hope you still have it on your list. It might not help, but you would find out very quickly whether it does or not. Research it a little first. You'll find some conficting opinions on its worth in treating OCD, but the literature to be found on Medline is encouraging.

This might seem far out - what about pindolol?

- Scott




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