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Re: Cymbalta, low-dosing - for med-sensitive types

Posted by jrbecker on August 25, 2004, at 10:00:53

In reply to Re: Cymbalta Samples-Question theo, posted by SLS on August 25, 2004, at 7:53:22

This strategy will probably only work for a very small minority of people since most will definitely have to push the dose up to 40-60mg to see beneficial results...but for those that want to be conservative and start low and go slow, here's some reassuring news.


Int Clin Psychopharmacol. 1997 May;12(3):137-40.

An open-label study of duloxetine hydrochloride, a mixed serotonin and noradrenaline reuptake inhibitor, in patients with DSM-III-R major depressive disorder. Lilly Duloxetine Depression Study Group.

Berk M, du Plessis AD, Birkett M, Richardt D.

Department of Psychiatry, University of the Witwatersrand, Johannesburg, South Africa.

Duloxetine hydrochloride, a mixed reuptake inhibitor of serotonin and noradrenaline, was studied in a 6 week open-label uncontrolled multicentre design at a dose of 20 mg daily both in in- and outpatients meeting DSM-III-R criteria for unipolar major depressive disorder. Seventy-nine patients took part in the study. The mean score on the 17-item Hamilton Depression Rating Scale at baseline was 24.9 (SD 4.4), decreasing to 8.5 (SD 7.8) after 6 weeks using a last observation carried forward analysis. Clinical response, defined as a 50% reduction in 17-item Hamilton Depression Rating Scale scores, occurred in 78.2% of patients, whereas remission, defined as a 17-item Hamilton Depression Rating Scale score of < or = 6, occurred in 60.3% of patients. Duloxetine hydrochloride was safe and well tolerated in this patient population.

PMID: 9248869 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9248869


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poster:jrbecker thread:378908
URL: http://www.dr-bob.org/babble/20040825/msgs/382088.html