Posted by Darla on August 23, 2004, at 12:01:45
In reply to Anyone had success on Effexor XR? , posted by jp on October 24, 1999, at 14:59:14
I have been doing a lot of research on this topic and i have some theories...
THEORY QUESTION: before i begin... I need someone to answer this..
INFO before question: It is stated that in Parkinson's Disease, L-Dopa is given (a dopamine supplement). Dopamine cannot be given because it doesnt pass the blood-brain barrier. Anyhow, Only 20% of L-Dopa gets past the barrier, ther rest goes into the peripheral nervous system and causes nausea, vomitting and shortness of breath.
QUESTION: is it possible that if your body was to produce too much dopamine, for IT to go to your PNS (peripheral nervous system)????If so, my theory is...
Your body goes into shock when usual amounts of serotonin and norepinephrine are not released.
What if dopamine was secreted as a supplement for serotonin-like feelings.
What if serotonin was rleased at a functionable rate and dopamine was therefore over-produced?If so, what if exceoss dopamine is transfered to the PNS?
**peripheral Nervous System= part of the central nervous system (ie. brain n spine) that sends messages.
This will cause nausea, vomitting and shirtness of breath.My theory continues.. a sub category of the PNS is the autonomic nervous system (beating of heart etc.), thereafter going into the sympathetic nervous system (readies body for response to threat, activates the organism.).
Therefore making your body feel as if there's an attack and it begins ward off this 'attack'. My theory s that your body begins to act as if its attacking the attacker.. this may cause the flu-like symptoms. Fever to burn bacteria and such.. vomitting out poison.. nausea, etc.
Also because the dopamine enters the central nervous system, it may be the cause of these "zaps" that feel like back spasms (pinched nerve in spine).
Because of the change in norepinephrine, the area concerning your adrenal glands may be affected.. I believe this could cause your body anxiety symptoms.. panic attacks, etc. Also PNS activation n sympathetic nervous system also makes panic attacks. "Surge of anxiety, tremors, profuse sweating, dry mouth, palpitating heart".THEORY 2:
Sympathetic and parasympathetic nervous systems work together. PARA calms body after attack therrefore "maintaining body's store of energy, such as regulating blood-sugar levels, secreting saliva, eliminating wastes, regulating heart rate and pupil size"
I think these are also withdrawal symptoms...Conclusion: If it is true and out body does over produce dopamine, then this could be the reson for winthdrawal symptoms. Also, this is the parts of the body that are targeted when we are pumped with norepinephrine and serotonin. So if this is the question.. we just need some answers...
THEORY 3:
If these theories stand to be somewhat correct.. and we are over producing dopamine during withdrawal, then isnt i possible to suffer from parkinsons disease-like symptoms if youve gone thu enough withdrawals (from going ona nd off too many drugs/??)If anyone actually reads all this 'psycho-babble', can you answer my q's to my theories?
I dont have to time to read this over, so pardon my errors.....
poster:Darla
thread:13781
URL: http://www.dr-bob.org/babble/20040821/msgs/381257.html